Uniparental Disomy (UPD) in Clinical Genetics
Liehr, Thomas.
Uniparental Disomy (UPD) in Clinical Genetics A Guide for Clinicians and Patients / [electronic resource] : by Thomas Liehr. - XVIII, 192 p. 36 illus., 26 illus. in color. online resource.
Introduction -- Formation of UPD -- UPD in diagnostics and genetic counseling -- UPD related syndromes caused by imprinting -- Maternal UPD by chromosome -- Paternal UPD by chromosome -- UPD of unclear parental origin by chromosome -- UPD of multiple chromosomes or chromosomal regions -- Acquired UPD -- Patient organizations in connection with UPD-. Glossary-. References -- Index.
This book focus on genetic diagnostics for Uniparental Disomy (UPD), a chromosomal disorder defined by the exceptional presence of a chromosome pair derived from only one parent, which leads to a group of rare diseases in humans. First the molecular and cytogenetic background of UPD is described in detail; subsequently, all available information of the various chromosomal origins and the latest findings on genotype-phenotype correlations and clinical consequences are discussed. Numerous personal reports from families with a child suffering from a UPD-induced syndrome serve to complement the scientific and clinical aspects. Their experiences with genetic counseling and living with a family member affected by this chromosomal aberration present a vivid picture of what UPD means for its victims.
9783642552885
10.1007/978-3-642-55288-5 doi
Medicine.
Human genetics.
Cytogenetics.
Laboratory medicine.
Reproductive medicine.
Biomedicine.
Human Genetics.
Cytogenetics.
Reproductive Medicine.
Laboratory Medicine.
RB155-155.8 QH431
611.01816 599.935
Uniparental Disomy (UPD) in Clinical Genetics A Guide for Clinicians and Patients / [electronic resource] : by Thomas Liehr. - XVIII, 192 p. 36 illus., 26 illus. in color. online resource.
Introduction -- Formation of UPD -- UPD in diagnostics and genetic counseling -- UPD related syndromes caused by imprinting -- Maternal UPD by chromosome -- Paternal UPD by chromosome -- UPD of unclear parental origin by chromosome -- UPD of multiple chromosomes or chromosomal regions -- Acquired UPD -- Patient organizations in connection with UPD-. Glossary-. References -- Index.
This book focus on genetic diagnostics for Uniparental Disomy (UPD), a chromosomal disorder defined by the exceptional presence of a chromosome pair derived from only one parent, which leads to a group of rare diseases in humans. First the molecular and cytogenetic background of UPD is described in detail; subsequently, all available information of the various chromosomal origins and the latest findings on genotype-phenotype correlations and clinical consequences are discussed. Numerous personal reports from families with a child suffering from a UPD-induced syndrome serve to complement the scientific and clinical aspects. Their experiences with genetic counseling and living with a family member affected by this chromosomal aberration present a vivid picture of what UPD means for its victims.
9783642552885
10.1007/978-3-642-55288-5 doi
Medicine.
Human genetics.
Cytogenetics.
Laboratory medicine.
Reproductive medicine.
Biomedicine.
Human Genetics.
Cytogenetics.
Reproductive Medicine.
Laboratory Medicine.
RB155-155.8 QH431
611.01816 599.935