Endogenous ADP-Ribosylation

      Endogenous ADP-Ribosylation [electronic resource] / edited by Friedrich Koch-Nolte. - VIII, 213 p. online resource. - Current Topics in Microbiology and Immunology, 384 0070-217X ; . - Current Topics in Microbiology and Immunology, 384 .

      The natural history of ADP-ribosyltransferases and the ADP ribosylation system -- Identification and Analysis of ADP-ribosylated Proteins -- Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine -- Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein -- Regulation of nitrogenase by reversible mono-ADP-ribosylation -- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells -- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish -- Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family -- Function and regulation of the mono-ADP-ribosyltransferase ARTD10 -- Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15.

      This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections:  ·   Evolution and detection of endogenous ADP-ribosylation  ·   ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs)   ·   ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs) The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.

      9783319107714

      10.1007/978-3-319-10771-4 doi


      Medicine.
      Immunology.
      Medical microbiology.
      Pharmacology.
      Biomedicine.
      Pharmacology/Toxicology.
      Medical Microbiology.
      Immunology.

      RM1-950

      615
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