MARC details
| 000 -LEADER |
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04918nam a22005055i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-1-4939-1227-8 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20160405110535.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
140822s2014 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781493912278 |
| -- |
978-1-4939-1227-8 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-1-4939-1227-8 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QH345 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QD415-436 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSB |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
SCI007000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
572 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Cardiac Energy Metabolism in Health and Disease |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Gary D. Lopaschuk, Naranjan S. Dhalla. |
| 264 #1 - |
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| -- |
New York, NY : |
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Springer New York : |
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Imprint: Springer, |
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2014. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XV, 295 p. 54 illus., 25 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - |
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text |
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txt |
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rdacontent |
| 337 ## - |
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computer |
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c |
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rdamedia |
| 338 ## - |
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online resource |
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cr |
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rdacarrier |
| 347 ## - |
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text file |
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PDF |
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rda |
| 490 1# - SERIES STATEMENT |
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| Series statement |
Advances in Biochemistry in Health and Disease ; |
| Volume number/sequential designation |
11 |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Part 1. Control of Energy Metabolism -- 1. A Primer on Carbohydrate Metabolism in the Heart -- 2. Lipoproteins: A Source of Cardiac Lipids -- 3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart -- 4. Control of Myocardial Fatty Acid Uptake -- 5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes -- 6. Transcriptional Control of Mitochondrial Biogenesis and Maturation -- 7. Relationship between Substrate Metabolism and Cardiac Efficiency -- 8. Acetylation in the Control of Mitochondrial Metabolism and Integrity -- Part 2. Alteration in Energy Metabolism -- 9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes -- 10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart -- 11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure -- 12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury -- 13. The Role of AMPK in the Control of Cardiac Hypertrophy -- 14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance -- Part 3. Optimization of Energy Metabolism -- 15. Metabolic Therapy for the Ischemic Heart -- 16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients -- 17. Cardiac Metabolic Protection for the Newborn Heart -- 18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy, and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional, and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction, and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Life sciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cardiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biochemistry. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Metabolism. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Life Sciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biochemistry, general. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Metabolomics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cardiology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Lopaschuk, Gary D. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dhalla, Naranjan S. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Display text |
Printed edition: |
| International Standard Book Number |
9781493912261 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
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| Uniform title |
Advances in Biochemistry in Health and Disease ; |
| Volume number/sequential designation |
11 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-1-4939-1227-8">http://dx.doi.org/10.1007/978-1-4939-1227-8</a> |
| 912 ## - |
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ZDB-2-SBL |
