MARC details
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04980nam a22004695i 4500 |
| 001 - CONTROL NUMBER |
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978-1-4939-1311-4 |
| 003 - CONTROL NUMBER IDENTIFIER |
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DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20160405110536.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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141112s2014 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781493913114 |
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978-1-4939-1311-4 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-1-4939-1311-4 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QR180-189.5 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MJCM |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED044000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.079 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Macrophages: Biology and Role in the Pathology of Diseases |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Subhra K. Biswas, Alberto Mantovani. |
| 264 #1 - |
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New York, NY : |
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Springer New York : |
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Imprint: Springer, |
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2014. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
IX, 615 p. 77 illus. |
| Other physical details |
online resource. |
| 336 ## - |
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text |
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txt |
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rdacontent |
| 337 ## - |
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computer |
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c |
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rdamedia |
| 338 ## - |
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online resource |
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cr |
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rdacarrier |
| 347 ## - |
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text file |
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PDF |
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rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Part I Macrophage: Origin, Activation And Polarization -- Blood monocytes and their subsets in health and disease -- Polarized activation of macrophages -- Alternative activation of macrophages: concepts and prospects -- Regulatory macrophages and the maintenance of homeostasis -- Part II Macrophages And Their Diverse Functions -- Phagocytosis -- The antimicrobial functions of macrophages -- Vascular modulatory functions of macrophages -- Part III Macrophages In Different Tissues -- Airway macrophages: sentinels of health -- Microglial ontogeny and functions in shaping brain circuits -- Kupffer cells in health and disease -- Intestinal Macrophages: Specialized antigen-presenting cells at the front line -- Part IV Macrophages In Pathology -- The wound macrophage - Macrophages and the entrance of resolution phase lipid mediators -- Macrophages in sepsis progression -- Adaptive characteristics of innate immune responses in macrophages -- African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection -- Macrophages in obesity and insulin resistance -- Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases -- Myelomonocytic subsets in tumor microenvironment -- Tumor associated macrophages -- Part V Transcriptional And Epigenetic Mechanisms -- Role of NF-kB activation in macrophages -- Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation -- Kruppel-like factors in Monocyte-Macrophage Biology -- Regulation of macrophage polarization by the STAT-SOCS signaling axis -- Functions of the large Maf transcription factors and macrophages -- The Control of Gene Expression in Macrophages -- Role of microRNA in macrophage activation and polarization -- Part VI Systems Biology Of Macrophages -- The macrophage transcriptome -- Omics approaches in macrophage biology -- Appendix. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue microenvironmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease- virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts to provide state-of-the art knowledge of these cells in health and disease. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Immunology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Antibodies. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medical microbiology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Immunology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Antibodies. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medical Microbiology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Biswas, Subhra K. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mantovani, Alberto. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Display text |
Printed edition: |
| International Standard Book Number |
9781493913107 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-1-4939-1311-4">http://dx.doi.org/10.1007/978-1-4939-1311-4</a> |
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ZDB-2-SBL |
