MARC details
| 000 -LEADER |
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04204nam a22005055i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-1-4614-7931-4 |
| 003 - CONTROL NUMBER IDENTIFIER |
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DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20160405111040.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
130808s2014 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9781461479314 |
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978-1-4614-7931-4 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-1-4614-7931-4 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RC261-271 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MJCL |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED062000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
614.5999 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Systems Analysis of Chromatin-Related Protein Complexes in Cancer |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Andrew Emili, Jack Greenblatt, Shoshana Wodak. |
| 264 #1 - |
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| -- |
New York, NY : |
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Springer New York : |
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Imprint: Springer, |
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2014. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XI, 316 p. |
| Other physical details |
online resource. |
| 336 ## - |
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text |
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txt |
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rdacontent |
| 337 ## - |
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computer |
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c |
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rdamedia |
| 338 ## - |
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online resource |
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cr |
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rdacarrier |
| 347 ## - |
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text file |
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PDF |
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rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Preface -- Systematic proteomic analysis of histone demethylating enzymes linked to cancer -- Histone methylating protein complexes in cancer -- Chromatin protein-protein interaction networks linked to cancer -- Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition -- Transcription factories and global chromatin (enhancer) interactions in cancer -- Long ncRNAs associated with chromatin complexes and their role in cancer -- Familial and somatic mutations of histone modifying enzymes in cancer -- Chromatin regulators arising from RNAi screens of transformed cancer cell lines -- Chromatin complexes in cancer -- Exploring dynamics of chromatin complexes in cancer based on quantitative proteomics -- Regulatory ncRNAs and their targets -- ncRNA regulatory networks in cancer -- Decoding BAF remodelling complexes in cancer -- Mediator/cohesin complex in cancer -- miRNAs targeting chromatin-related protein complexes regulate epigenetic states in cancer -- Polycomb group protein complexes in cancer stem cells -- Genetic interactions between chromatin factors in cancer cell lines -- Chromatin complexes in DNA repair -- Chromatin complexes in chromosome segregation -- Evolution, co-expression and domain architecture of CM complexes linked to cancer -- Index. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned “on” or “off” and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cancer research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Human genetics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Proteomics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Systems biology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cancer Research. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Systems Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Human Genetics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Proteomics. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Emili, Andrew. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Greenblatt, Jack. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wodak, Shoshana. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Display text |
Printed edition: |
| International Standard Book Number |
9781461479307 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-1-4614-7931-4">http://dx.doi.org/10.1007/978-1-4614-7931-4</a> |
| 912 ## - |
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ZDB-2-SBL |
