MARC details
| 000 -LEADER |
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04123nam a22005175i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-3-319-16850-0 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20160405112857.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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150420s2015 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783319168500 |
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978-3-319-16850-0 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-3-319-16850-0 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QD431-431.7 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSBC |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
SCI007000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
572.6 |
| Edition number |
23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Fernández Stigliano, Ariel. |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
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| Title |
Biomolecular Interfaces |
| Medium |
[electronic resource] : |
| Remainder of title |
Interactions, Functions and Drug Design / |
| Statement of responsibility, etc |
by Ariel Fernández Stigliano. |
| 264 #1 - |
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Cham : |
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Springer International Publishing : |
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Imprint: Springer, |
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2015. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XIX, 372 p. 145 illus., 86 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - |
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text |
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txt |
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rdacontent |
| 337 ## - |
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computer |
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c |
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rdamedia |
| 338 ## - |
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online resource |
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cr |
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rdacarrier |
| 347 ## - |
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text file |
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PDF |
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rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
The Aqueous Interface of a Soluble Protein or the Birth of Epistructural Biology -- Electrostatic Exploration of Biomolecular Interfaces: The Chemical Function of Interfacial Water -- Semiempirical Solution to the Protein Folding Problem Through a Combination of Structural and Epistructural Approaches -- Packing Defects and Protein Hydration: Dynamics of the Aqueous Interface -- Proteins in the Order-Disorder Twilight: Unstable Interfaces Promote Protein Aggregation -- Evolution of Protein Structure Degradation and Lessons for the Drug Designer -- Chemical Functionality of the Aqueous Interface in Soluble Proteins -- The Biomolecular Interface as a Selectivity Filter for Drug-Based Targeted Therapy -- Wrapping-Based Re-Engineering of an Anticancer Drug to Make it Safer -- Biomolecular Interfaces Provide Universal Markers for Drug Specificity and Personalized Medicine -- Controlling Induced Folding Through Wrapping Drug Design -- Wrapping Drug Combinations for Therapeutic Editing of Side Effects: Systems Biology Meets Wrapping Technology -- Multi-Target Control of Drug Impact: A Therapeutic Imperative in Cancer Systems Biology -- Engineering Therapeutic Alignments between Immune Response and Molecularly Targeted Cancer Treatment -- High-Level Quantum Chemistry Empowers the Wrapping Technology for Drug Design -- Epilogue -- Appendix 1. Code for Dehydron Identification -- Appendix 2. Solutions of Problems. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and biomolecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Life sciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Molecular biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Pharmaceutical technology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Proteins. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cell membranes. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biophysics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biological physics. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Life Sciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Protein-Ligand Interactions. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Membrane Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Molecular Medicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Pharmaceutical Sciences/Technology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biophysics and Biological Physics. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Display text |
Printed edition: |
| International Standard Book Number |
9783319168494 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-3-319-16850-0">http://dx.doi.org/10.1007/978-3-319-16850-0</a> |
| 912 ## - |
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ZDB-2-SBL |
