MARC details
| 000 -LEADER |
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| fixed length control field |
04966nam a22004935i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-3-319-17437-2 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20160405112900.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
150629s2015 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783319174372 |
| -- |
978-3-319-17437-2 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-3-319-17437-2 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QH573-671 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSF |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
SCI049000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
571.6 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Cardiac Fibrosis and Heart Failure: Cause or Effect? |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Ian M.C. Dixon, Jeffrey T. Wigle. |
| 264 #1 - |
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| -- |
Cham : |
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Springer International Publishing : |
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Imprint: Springer, |
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2015. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XV, 436 p. 73 illus., 59 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - |
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text |
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txt |
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rdacontent |
| 337 ## - |
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computer |
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c |
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rdamedia |
| 338 ## - |
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| -- |
online resource |
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cr |
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rdacarrier |
| 347 ## - |
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| -- |
text file |
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PDF |
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rda |
| 490 1# - SERIES STATEMENT |
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| Series statement |
Advances in Biochemistry in Health and Disease ; |
| Volume number/sequential designation |
13 |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
1. Fibrosis and Heart Failure - Cause or Effect? -- 2. Fibroblast Activation in the Infarcted Myocardium -- 3. Mechanical and Matrix Regulation of Valvular Fibrosis -- 4. Bone Marrow-Derived Progenitor Cells, micro-RNA and Fibrosis -- 5. The Stressful Life of Cardiac Myofibroblasts -- 6. Pathogenic Origins of Fibrosis in the Hypertensive Heart Disease that Accompanies Aldosteronism -- 7. Embryological origin of valve progenitor cells -- 8. Diverse cellular origins of cardiac fibroblasts -- 9. Non-Canonical Regulation of TGF-β1 Signaling: A Role for Ski/Sno and YAP/TAZ -- 10. Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heart -- 11. Current and future strategies for the diagnosis and treatment of cardiac fibrosis -- 12. Remodelling of the cardiac extracellular matrix: Role of collagen degradation and accumulation in pathogenesis of heart failure -- 13. Matrix Metalloproteinase 9 (MMP-9): The Middle-Man of Post Myocardial Infarction Extracellular Matrix Remodelling -- 14. Collagen processing and its role in Fibrosis -- 15. Mechanisms of Cardiac Fibrosis -- 16. Mathematical Simulations of Sphingosine-1-Phosphate Actions on Mammalian Ventricular Myofibroblasts and Myocytes -- 17. Extracellular Matrix and Cardiac Disease: Surgical and Scientific Perspectives -- 18. The Role of Neurohumoral Activation in Cardiac Fibrosis and Heart Failure -- 19. Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart -- 20. Cardiac Tissue Engineering for the Treatment of Heart Failure Post-Infarction -- 21. Mechanisms of Cardiac Valve Failure and the Development of Tissue Engineered Heart Valves. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
The unique biology of cardiac fibroblasts and related cells, such as cardiac myofibroblasts and valvular interstitial cells, distinguish them from other fibroblastic cells, a concept that is only beginning to be widely appreciated. Further, the natural signals that stimulate and inhibit cardiac fibrosis within these cells are not well understood. This volume compiles articles that address the molecular mechanisms that control the synthesis and secretion of the cardiac ECM. The book showcases chapters that highlight discussion of role of Transforming Growth Factor β (TGFβ), an important fibrogenic cytokine, and its downstream effectors SMAD in many cardiac diseases. Further, the contributions highlight information to discuss endogenous inhibitors of cardiac fibrosis, as well as advances in tissue engineering specific to matrix in the heart. Finally, discussions of unifying mechanisms of matrix remodeling in valves and myocardium are presented. The mechanisms involved in the stimulation of cardiac fibrosis are not fully understood. In most cases the marginal attenuation of cardiac fibrosis as a result of a given therapy is a beneficial side-effect linked to other primary effects on other cells, especially cardiomyocytes. Very few drugs or agents are known to affect the function and dysfunction of cardiac fibroblasts and myofibroblasts alone. The book helps to translate the information gathered within to allow us to alter the course of fibrogenic events that are typical of cardiac fibrosis, and thereby reduce their burden on the patient and on society itself. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Life sciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Molecular biology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cardiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cell biology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Life Sciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cell Biology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cardiology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Molecular Medicine. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Dixon, Ian M.C. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Wigle, Jeffrey T. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Display text |
Printed edition: |
| International Standard Book Number |
9783319174365 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
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| Uniform title |
Advances in Biochemistry in Health and Disease ; |
| Volume number/sequential designation |
13 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-3-319-17437-2">http://dx.doi.org/10.1007/978-3-319-17437-2</a> |
| 912 ## - |
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ZDB-2-SBL |
