MARC details
| 000 -LEADER |
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03820nam a22005295i 4500 |
| 001 - CONTROL NUMBER |
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978-3-319-19285-7 |
| 003 - CONTROL NUMBER IDENTIFIER |
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DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20160405112907.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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cr nn 008mamaa |
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150929s2015 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783319192857 |
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978-3-319-19285-7 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-3-319-19285-7 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
RC321-580 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
PSAN |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED057000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
612.8 |
| Edition number |
23 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Rüb, Udo. |
| Relator term |
author. |
| 245 14 - TITLE STATEMENT |
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| Title |
The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
by Udo Rüb, Jean Paul G. Vonsattel, Helmut Heinsen, Horst-Werner Korf. |
| 250 ## - EDITION STATEMENT |
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| Edition statement |
1st ed. 2015. |
| 264 #1 - |
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Cham : |
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Springer International Publishing : |
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Imprint: Springer, |
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2015. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
XIV, 146 p. 50 illus., 47 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - |
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text |
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txt |
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rdacontent |
| 337 ## - |
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computer |
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c |
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rdamedia |
| 338 ## - |
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online resource |
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cr |
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rdacarrier |
| 347 ## - |
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text file |
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PDF |
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rda |
| 490 1# - SERIES STATEMENT |
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| Series statement |
Advances in Anatomy, Embryology and Cell Biology, |
| International Standard Serial Number |
0301-5556 ; |
| Volume number/sequential designation |
217 |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
1. Introduction -- 2. The neuropathological grading of Huntington disease -- 3. The cerebral cortex in Huntington´s disease -- 4. Degeneration of select motor and limbic nuclei of the thalamus in Huntington’s disease -- 5. Consistent and widespread degeneration of the cerebellum in Huntington’s disease -- 6. Elucidation of the role of the premotor oculomotor brainstem nuclei in the pathogenesis of oculomotor dysfunctions in Huntington’s disease -- 7. Widespread brainstem neurodegeneration in Huntington’s disease -- 8. Intraneuronal transport and defense mechanisms with possible pathogenetic relevance in Huntington’s disease -- 9. The disease protein huntingtin and neuronal protein aggregations in Huntington’s disease -- 10. Pathological nerve cell alterations in Huntington’s disease (HD) and their possible role for the demise of nerve cells -- 11. Conclusions and outlook. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Human genetics. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Neurosciences. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Pathology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Neurosciences. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Human Genetics. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Pathology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Vonsattel, Jean Paul G. |
| Relator term |
author. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Heinsen, Helmut. |
| Relator term |
author. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Korf, Horst-Werner. |
| Relator term |
author. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Display text |
Printed edition: |
| International Standard Book Number |
9783319192840 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
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| Uniform title |
Advances in Anatomy, Embryology and Cell Biology, |
| -- |
0301-5556 ; |
| Volume number/sequential designation |
217 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-3-319-19285-7">http://dx.doi.org/10.1007/978-3-319-19285-7</a> |
| 912 ## - |
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ZDB-2-SBL |
