MARC details
| 000 -LEADER |
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| fixed length control field |
04250nam a22005055i 4500 |
| 001 - CONTROL NUMBER |
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| control field |
978-3-319-21100-8 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20160405112918.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
150801s2015 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
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| International Standard Book Number |
9783319211008 |
| -- |
978-3-319-21100-8 |
| 024 7# - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/978-3-319-21100-8 |
| Source of number or code |
doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER |
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| Classification number |
QR355-502 |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MMFM |
| Source |
bicssc |
| 072 #7 - SUBJECT CATEGORY CODE |
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| Subject category code |
MED052000 |
| Source |
bisacsh |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
616.9101 |
| Edition number |
23 |
| 245 10 - TITLE STATEMENT |
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| Title |
Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer |
| Medium |
[electronic resource] / |
| Statement of responsibility, etc |
edited by Daniel L. Miller, M. Sharon Stack. |
| 250 ## - EDITION STATEMENT |
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| Edition statement |
1st ed. 2015. |
| 264 #1 - |
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| -- |
Cham : |
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Springer International Publishing : |
| -- |
Imprint: Springer, |
| -- |
2015. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
VIII, 314 p. 29 illus., 22 illus. in color. |
| Other physical details |
online resource. |
| 336 ## - |
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| -- |
text |
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txt |
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rdacontent |
| 337 ## - |
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computer |
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c |
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rdamedia |
| 338 ## - |
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| -- |
online resource |
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cr |
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rdacarrier |
| 347 ## - |
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| -- |
text file |
| -- |
PDF |
| -- |
rda |
| 505 0# - FORMATTED CONTENTS NOTE |
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| Formatted contents note |
Epidemiology of HPV-Associated Oropharyngeal Squamous Cell Carcinoma -- Behavioral Correlates of HPV-Associated Oropharyngeal Squamous Cell Carcinomas -- Racial Disparities in Oropharyngeal Cancer -- HPV Virology: Cellular Targets of HPV Oncogenes and Transformation -- Papillomavirus Replication -- MicroRNA Profiles of HPV-Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) -- Targeting the PI3K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies -- Mutational Profile of HPV-Positive HNSCC -- Clinical Presentation of HPV-driven Oropharyngeal Carcinoma -- Differences and Similarities between HPV-Associated OPSCC and Cervical Cancer -- Surgical Perspective in the Management of Oropharyngeal Cancer -- HPV and Radiation Sensitivity -- The Role of Immune Modulation in the Carcinogenesis and Treatment of HPV-associated Oropharyngeal Cancer. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
Head and neck squamous cell carcinoma (HNSCC), the sixth most prevalent cancer worldwide, remains a very difficult disease to treat and cure despite intensive investigation into molecular etiologies and tumor progression pathways. Due to public health efforts encouraging smoking cessation, the overall incidence of HNSCC has decreased in recent years in many countries. In contrast, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased significantly, and this subtype of HNSCC is commonly associated with human papillomavirus (HPV) infection. Moreover, individuals with HPV-positive OPSCC are generally younger and are frequently non-smokers, suggesting that HPV-associated OPSCC represents a distinct biologic entity. This volume summarizes the spectrum of current HPV-associated OPSCC research from the fundamental basic science to translational surgery and treatment approaches. Chapters are contributed by authoritative leaders in the fields of research and clinical care. Initial chapters address epidemiology, behavioral correlates of HPV infection, and racial disparities in oropharyngeal cancer. This is followed by chapters detailing HPV virology with focus on viral transformation, viral replication, and host response to viral infection. The molecular biology of HPV-associated OPSCC is investigated in chapters detailing alterations in signaling networks and unique mutational profiles of human tumors. Clinical presentation, surgical perspectives, and treatment paradigms specific to HPV-associated OPSCC conclude the volume. This comprehensive volume provides an up-to-date overview of both scientific discovery and clinical management of this emerging public health problem. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medicine. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cancer research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Immunology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medical microbiology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Virology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Biomedicine. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Virology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Cancer Research. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Immunology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Medical Microbiology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Miller, Daniel L. |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Stack, M. Sharon. |
| Relator term |
editor. |
| 710 2# - ADDED ENTRY--CORPORATE NAME |
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| Corporate name or jurisdiction name as entry element |
SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY |
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| Title |
Springer eBooks |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
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| Display text |
Printed edition: |
| International Standard Book Number |
9783319210995 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS |
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| Uniform Resource Identifier |
<a href="http://dx.doi.org/10.1007/978-3-319-21100-8">http://dx.doi.org/10.1007/978-3-319-21100-8</a> |
| 912 ## - |
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| -- |
ZDB-2-SBL |
