The halophiles are a large unexplored reservoir of biodiversity and are a potential source for  industry, agriculture and environment. The highlights include the distribution of the halophiles, their adaptation in different stress conditions, and mining of their unique antimicrobial and enzymatic potential. These poly extremophiles are excellent source of enzymes and metabolites possessing inherent ability to function in extreme conditions viz., high salt, alkaline pH and facilitating catalysis for biotechnological application in food processing, industrial bioconversion and bioremediation. In brief, we have just begun to realize the great potential and true extent of diversity and suitable industrial applications possible from halophiles.