Part 1: Oxidative Stress: Basic Principles in the Liver Scenario -- Principles of Redox Signaling -- Oxidative Stress, Antioxidant Defenses and the Liver -- Oxidative Mechanisms in Liver Senescence and Regeneration -- Part 2: Oxidative Stress and Liver Pathophysiology: From Cell Damage and Death to Inflammatory and Fibrogenic Responses -- Oxidative Stress and Hepatocellular Injury -- Oxidative Stress and the Unfolded Protein Response in the Liver -- Oxidative Stress and Liver Inflammation -- Oxidative Stress and Liver Ischemia-Reperfusion Injury -- Oxidative Stress and Liver Fibrogenesis -- Part 3: Oxidative Stress in Specific Liver Disease Conditions -- Oxidative Stress in Acute Liver Failure -- Oxidative Stress in Alcoholic Liver Disease -- Oxidative Stress in Chronic Viral Hepatitis -- Oxidative Stress in Nonalcoholic Fatty Liver Disease -- Oxidative Stress in Non-autoimmune Biliary Diseases -- Oxidative Stress in Autoimmune Liver Diseases -- Oxidative Stress and Hepatic Iron Overload -- Oxidative Stress in the Central Nervous System Complications of Chronic Liver Failure -- Oxidative Stress and Liver Transplantation -- Antioxidant Approach to the Therapy of Chronic Liver Disease -- Part 4: Oxidative Stress and Liver Cancer -- Liver Cancer Classification -- Oxidative Stress Mechanisms in Hepatocarcinogenesis -- The Role of Oxidative Stress in Hepatocarcinogenesis.

This volume examines the impact of free radical biology on hepatic disorders such as viral hepatitis, alcoholic disease, iron overload, and Wilson’s disease. It thoroughly explores the role of oxidative stress in acute and chronic disease, addressing factors such as redox biomarkers; antioxidant defense and protection; cell signaling; mutations; oxidative damage involving lipids, proteins, and nucleic acids; membrane trafficking; inflammation; mitochondrial dysfunction; alterations in immunological function; toxicology; and hypoxia. Its four sections, consisting of chapters by recognized field leaders, deal with basic principles of oxidation and hepatology, oxidative stress-related pathophysiology, oxidative stress and liver disease, and liver cancer. Intuitively structured and comprehensive, Studies on Hepatic Disorders is an invaluable addition to the Oxidative Stress in Applied Basic Research and Clinical Practice series and an essential resource for clinical hepatologists and researchers interested in the role of oxidative stress on liver function and disease.