000 04918nam a22005055i 4500
001 978-1-4939-1227-8
003 DE-He213
005 20160405110535.0
007 cr nn 008mamaa
008 140822s2014 xxu| s |||| 0|eng d
020 _a9781493912278
_9978-1-4939-1227-8
024 7 _a10.1007/978-1-4939-1227-8
_2doi
050 4 _aQH345
050 4 _aQD415-436
072 7 _aPSB
_2bicssc
072 7 _aSCI007000
_2bisacsh
082 0 4 _a572
_223
245 1 0 _aCardiac Energy Metabolism in Health and Disease
_h[electronic resource] /
_cedited by Gary D. Lopaschuk, Naranjan S. Dhalla.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aXV, 295 p. 54 illus., 25 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Biochemistry in Health and Disease ;
_v11
505 0 _aPart 1. Control of Energy Metabolism -- 1. A Primer on Carbohydrate Metabolism in the Heart -- 2. Lipoproteins: A Source of Cardiac Lipids -- 3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart -- 4. Control of Myocardial Fatty Acid Uptake -- 5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes -- 6. Transcriptional Control of Mitochondrial Biogenesis and Maturation -- 7. Relationship between Substrate Metabolism and Cardiac Efficiency -- 8. Acetylation in the Control of Mitochondrial Metabolism and Integrity -- Part 2. Alteration in Energy Metabolism -- 9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes -- 10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart -- 11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure -- 12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury -- 13. The Role of AMPK in the Control of Cardiac Hypertrophy -- 14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance -- Part 3. Optimization of Energy Metabolism -- 15. Metabolic Therapy for the Ischemic Heart -- 16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients -- 17. Cardiac Metabolic Protection for the Newborn Heart -- 18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease.
520 _aThe heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP.  The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy, and any change in this energy supply can seriously compromise cardiac function.  It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease.  It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional, and physiological levels.  It also describes how alterations in energy metabolism contribute to the development of heart dysfunction, and how optimization of energy metabolism can be used to treat heart disease.  The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics.  The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
650 0 _aLife sciences.
650 0 _aCardiology.
650 0 _aBiochemistry.
650 0 _aMetabolism.
650 1 4 _aLife Sciences.
650 2 4 _aBiochemistry, general.
650 2 4 _aMetabolomics.
650 2 4 _aCardiology.
700 1 _aLopaschuk, Gary D.
_eeditor.
700 1 _aDhalla, Naranjan S.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781493912261
830 0 _aAdvances in Biochemistry in Health and Disease ;
_v11
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4939-1227-8
912 _aZDB-2-SBL
999 _c2814
_d2814