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001 978-1-4939-1311-4
003 DE-He213
005 20160405110536.0
007 cr nn 008mamaa
008 141112s2014 xxu| s |||| 0|eng d
020 _a9781493913114
_9978-1-4939-1311-4
024 7 _a10.1007/978-1-4939-1311-4
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aMacrophages: Biology and Role in the Pathology of Diseases
_h[electronic resource] /
_cedited by Subhra K. Biswas, Alberto Mantovani.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2014.
300 _aIX, 615 p. 77 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I Macrophage: Origin, Activation And Polarization -- Blood monocytes and their subsets in health and disease -- Polarized activation of macrophages -- Alternative activation of macrophages: concepts and prospects -- Regulatory macrophages and the maintenance of homeostasis -- Part II Macrophages And Their Diverse Functions -- Phagocytosis -- The antimicrobial functions of macrophages -- Vascular modulatory functions of macrophages -- Part III Macrophages In Different Tissues -- Airway macrophages: sentinels of health -- Microglial ontogeny and functions in shaping brain circuits -- Kupffer cells in health and disease -- Intestinal Macrophages: Specialized antigen-presenting cells at the front line -- Part IV Macrophages In Pathology -- The wound macrophage - Macrophages and the entrance of resolution phase lipid mediators -- Macrophages in sepsis progression -- Adaptive characteristics of innate immune responses in macrophages -- African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection -- Macrophages in obesity and insulin resistance -- Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases -- Myelomonocytic subsets in tumor microenvironment -- Tumor associated macrophages -- Part V Transcriptional And Epigenetic Mechanisms -- Role of NF-kB activation in macrophages -- Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation -- Kruppel-like factors in Monocyte-Macrophage Biology -- Regulation of macrophage polarization by the STAT-SOCS signaling axis -- Functions of the large Maf transcription factors and macrophages -- The Control of Gene Expression in Macrophages -- Role of microRNA in macrophage activation and polarization -- Part VI Systems Biology Of Macrophages -- The macrophage transcriptome -- Omics approaches in macrophage biology -- Appendix.
520 _aMacrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue microenvironmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease- virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts to provide state-of-the art knowledge of these cells in health and disease.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aAntibodies.
650 0 _aMedical microbiology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aAntibodies.
650 2 4 _aMedical Microbiology.
700 1 _aBiswas, Subhra K.
_eeditor.
700 1 _aMantovani, Alberto.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781493913107
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4939-1311-4
912 _aZDB-2-SBL
999 _c2818
_d2818