000 | 04454nam a22004815i 4500 | ||
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001 | 978-4-431-54442-5 | ||
003 | DE-He213 | ||
005 | 20160405110626.0 | ||
007 | cr nn 008mamaa | ||
008 | 131028s2014 ja | s |||| 0|eng d | ||
020 |
_a9784431544425 _9978-4-431-54442-5 |
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024 | 7 |
_a10.1007/978-4-431-54442-5 _2doi |
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050 | 4 | _aQR180-189.5 | |
072 | 7 |
_aMJCM _2bicssc |
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072 | 7 |
_aMED044000 _2bisacsh |
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082 | 0 | 4 |
_a616.079 _223 |
245 | 1 | 0 |
_aCytokine Frontiers _h[electronic resource] : _bRegulation of Immune Responses in Health and Disease / _cedited by Takayuki Yoshimoto, Tomohiro Yoshimoto. |
264 | 1 |
_aTokyo : _bSpringer Japan : _bImprint: Springer, _c2014. |
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300 |
_aXII, 396 p. 44 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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505 | 0 | _aPart I Cytokines in Inflammatory Disorders -- 1 The Interleukin-1 Family2 IL-6 and Inflammatory Diseases -- 3 The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders -- 4 IL-18 -- 5 Interleukin-21: A Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential -- 6 Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells -- 7 IL-23 in Health and Disease -- 8 IL-36: An Epithelial Cytokine Important in Psoriasis -- 9 Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure -- Part II Cytokines in Allergic Disorders -- 10 Interleukin-25: A Key Initiator of Type 2 Immune Responses -- 11 Interleukin-33: A Multifunctional Alarmin that Promotes Both Health and Disease -- 12 Thymic Stromal Lymphopoietin (TSLP) -- Part III Cytokines in Immunological Tolerance and Anti-inflammation -- 13 Interleukin-10: Cytokines in Anti-inflammation and Tolerance -- 14 Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties -- 15 Interleukin-35: A Novel Mediator of Peripheral Tolerance -- Index. . | |
520 | _aThis book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aImmunology. | |
650 | 0 | _aCytokines. | |
650 | 0 | _aGrowth factors. | |
650 | 0 | _aCell biology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aImmunology. |
650 | 2 | 4 | _aCytokines and Growth Factors. |
650 | 2 | 4 | _aCell Biology. |
700 | 1 |
_aYoshimoto, Takayuki. _eeditor. |
|
700 | 1 |
_aYoshimoto, Tomohiro. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9784431544418 |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-4-431-54442-5 |
912 | _aZDB-2-SBL | ||
999 |
_c3059 _d3059 |