000 04454nam a22004815i 4500
001 978-4-431-54442-5
003 DE-He213
005 20160405110626.0
007 cr nn 008mamaa
008 131028s2014 ja | s |||| 0|eng d
020 _a9784431544425
_9978-4-431-54442-5
024 7 _a10.1007/978-4-431-54442-5
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
245 1 0 _aCytokine Frontiers
_h[electronic resource] :
_bRegulation of Immune Responses in Health and Disease /
_cedited by Takayuki Yoshimoto, Tomohiro Yoshimoto.
264 1 _aTokyo :
_bSpringer Japan :
_bImprint: Springer,
_c2014.
300 _aXII, 396 p. 44 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I Cytokines in Inflammatory Disorders -- 1 The Interleukin-1 Family2 IL-6 and Inflammatory Diseases -- 3 The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders -- 4 IL-18 -- 5 Interleukin-21: A Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential -- 6 Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells -- 7 IL-23 in Health and Disease -- 8 IL-36: An Epithelial Cytokine Important in Psoriasis -- 9 Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure -- Part II Cytokines in Allergic Disorders -- 10 Interleukin-25: A Key Initiator of Type 2 Immune Responses -- 11 Interleukin-33: A Multifunctional Alarmin that Promotes Both Health and Disease -- 12 Thymic Stromal Lymphopoietin (TSLP) -- Part III Cytokines in Immunological Tolerance and Anti-inflammation -- 13 Interleukin-10: Cytokines in Anti-inflammation and Tolerance -- 14 Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties -- 15 Interleukin-35: A Novel Mediator of Peripheral Tolerance -- Index.  .
520 _aThis book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aCytokines.
650 0 _aGrowth factors.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aCytokines and Growth Factors.
650 2 4 _aCell Biology.
700 1 _aYoshimoto, Takayuki.
_eeditor.
700 1 _aYoshimoto, Tomohiro.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9784431544418
856 4 0 _uhttp://dx.doi.org/10.1007/978-4-431-54442-5
912 _aZDB-2-SBL
999 _c3059
_d3059