000			03659nam a22004815i 4500
001			978-4-431-55052-5
003			DE-He213
005			20160405110629.0
007			cr nn 008mamaa
008			140819s2014 ja | s |||| 0|eng d
020			_a9784431550525 _9978-4-431-55052-5
024	7		_a10.1007/978-4-431-55052-5 _2doi
050		4	_aQH345
050		4	_aQD415-436
072		7	_aPSB _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572 _223
245	1	0	_aRegulatory Nascent Polypeptides _h[electronic resource] / _cedited by Koreaki Ito.
264		1	_aTokyo : _bSpringer Japan : _bImprint: Springer, _c2014.
300			_aIX, 315 p. 75 illus., 62 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
520			_aThis book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a halt in the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outputs such as elevation or reduction of a gene product. This book provides a first collection of knowledge focused on regulatory nascent polypeptides, which have been studied recently using diverse organisms including bacteria, plants, and animals. Readers will be impressed by a new paradigm showing that proteins can function even during the course of their biosynthesis and that the ribosome, the "factory" of protein production, interacts with and inspects its products to adjust the speed of completion of each product. Moreover, regulatory nascent polypeptides can sense or monitor physiological states of the cell and modulate its ability to arrest translation. Living organisms use such intricate control mechanisms of translational speed to regulate gene expression. This book will be a useful addition for established scientists while inspiring students and young scientists to gain deeper insights into the processes of expression of genetic information.
650		0	_aLife sciences.
650		0	_aHuman genetics.
650		0	_aGene expression.
650		0	_aBiochemistry.
650		0	_aCell biology.
650	1	4	_aLife Sciences.
650	2	4	_aBiochemistry, general.
650	2	4	_aCell Biology.
650	2	4	_aHuman Genetics.
650	2	4	_aGene Expression.
700	1		_aIto, Koreaki. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9784431550518
856	4	0	_uhttp://dx.doi.org/10.1007/978-4-431-55052-5
912			_aZDB-2-SBL
999			_c3071 _d3071