| 000 | 03732nam a22004575i 4500 | ||
|---|---|---|---|
| 001 | 978-1-4614-8039-6 | ||
| 003 | DE-He213 | ||
| 005 | 20160405111040.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 130823s2014 xxu| s |||| 0|eng d | ||
| 020 |
_a9781461480396 _9978-1-4614-8039-6 |
||
| 024 | 7 |
_a10.1007/978-1-4614-8039-6 _2doi |
|
| 050 | 4 | _aRC261-271 | |
| 072 | 7 |
_aMJCL _2bicssc |
|
| 072 | 7 |
_aMED062000 _2bisacsh |
|
| 082 | 0 | 4 |
_a614.5999 _223 |
| 245 | 1 | 0 |
_aNuclear Signaling Pathways and Targeting Transcription in Cancer _h[electronic resource] / _cedited by Rakesh Kumar. |
| 264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Humana Press, _c2014. |
|
| 300 |
_aXII, 439 p. _bonline resource. |
||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
||
| 490 | 1 |
_aCancer Drug Discovery and Development, _x2196-9906 |
|
| 505 | 0 | _aPreface -- Steroid Receptor Coactivators (SRCs) as Integrators of Multiple Signaling Pathways in Cancer Progression -- Role of Alteration/Deficiency in Activation (ADA) Complex in the Cell Cycle, Genomic Instability and Cancer -- RUNX2 Transcriptional Regulation in Development and Disease -- Epigenetic Mechanisms of Cancer Metastasis -- Regulatory Effects of Arsenic on Cellular Signaling Pathways: Biological Effects and Therapeutic Implications -- Nuclear Factors Linking Cancer and Inflammation -- Regulation of the Jak/STATs Pathways by Histone Deacetylases -- Receptor Tyrosine Kinases in the Nucleus: Nuclear Functions and Therapeutic Implications in Cancers -- Nucleolar Signaling Determines Cell Fate – The RP-Mdm2-p53 Axis Fine-Tunes Cellular Homeostasis -- Transcriptional Regulation of Lipogenesis as a Therapeutic Target for Cancer Treatment -- Selective Inhibition of Acetyl-Lysine Effector Domains of the Bromodomain Family in Oncology -- Domain Specific Targeting of Cancer -- The Potential of Targeting Splicing for Cancer Therapy -- Exploiting Cell Cycle Pathways in Cancer Therapy: New (and Old) Targets and Potential Strategies -- Histone Demethylases in Prostate Cancer -- Therapeutic Significance of Chromatin Remodeling Complexes in Cancer -- Index. | |
| 520 | _aThis book presents the most up-to-date information in the area of targeted therapeutics with a particular focus on pathway-centered approaches and transcription by leading authorities in molecular cancer research. The goal is to cover several critical principles of cancer therapeutics, ranging from regulation of cancer associated genes by coregulators, cancer cell signaling, modifiers of epigenome functionality and specific protein domains, and emerging significance of splicing. The book is directed for basic and translational scientists, clinicians, clinical investigators, fellows, residents, graduate students, and educators in the areas of molecular therapeutics and cancer medicine, and medical sciences at-large. Readers will be able to grasp the overall importance of the pathway, associated pathobiology and clinical manifestation, and possible points of intervention with a goal to solidify new cancer therapeutic targets. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aCancer research. | |
| 650 | 0 | _aPharmacology. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aCancer Research. |
| 650 | 2 | 4 | _aPharmacology/Toxicology. |
| 700 | 1 |
_aKumar, Rakesh. _eeditor. |
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| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781461480389 |
| 830 | 0 |
_aCancer Drug Discovery and Development, _x2196-9906 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-8039-6 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c3247 _d3247 |
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