000			03034nam a22005295i 4500
001			978-1-4614-8444-8
003			DE-He213
005			20160405111043.0
007			cr nn 008mamaa
008			131028s2014 xxu| s |||| 0|eng d
020			_a9781461484448 _9978-1-4614-8444-8
024	7		_a10.1007/978-1-4614-8444-8 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
245	1	0	_aNon-coding RNAs and Cancer _h[electronic resource] / _cedited by Muller Fabbri.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014.
300			_aVI, 284 p. 19 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction -- Biogenesis and Physiology of microRNAs.-Detecting non-coding RNA expression: from arrays to next generation sequencing -- MicroRNAs in Solid Tumors.-MicroRNAs in hematologic malignancies -- miRNAs as Cancer Biomarkers -- Unraveling the complex network of interactions between non-coding RNAs and epigenetics in cancer -- MicroRNA SNPs in Cancer -- Bioinformatics Approaches to the study of microRNAs -- Beyond miRNAs: role of other non-coding RNAs in cancer -- Translational Implications for non-coding RNA in Cancer -- Index.
520			_aThe discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.
650		0	_aMedicine.
650		0	_aCancer research.
650		0	_aHuman genetics.
650		0	_aGene expression.
650		0	_aBiochemistry.
650		0	_aPosttranslational modification.
650		0	_aCell biology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aCell Biology.
650	2	4	_aBiochemistry, general.
650	2	4	_aPosttranslational Modification.
650	2	4	_aGene Expression.
650	2	4	_aHuman Genetics.
700	1		_aFabbri, Muller. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461484431
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-8444-8
912			_aZDB-2-SBL
999			_c3258 _d3258