000			03300nam a22004695i 4500
001			978-1-4614-8642-8
003			DE-He213
005			20160405111044.0
007			cr nn 008mamaa
008			131108s2014 xxu| s |||| 0|eng d
020			_a9781461486428 _9978-1-4614-8642-8
024	7		_a10.1007/978-1-4614-8642-8 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
245	1	4	_aThe Genetics of Obesity _h[electronic resource] / _cedited by Struan F.A. Grant.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2014.
300			_aVIII, 128 p. 11 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aGenetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies -- Genetic Obesity Syndromes -- Genome-Wide Association Studies of Obesity -- Copy Number Variants and their Contribution to the Risk of Obesity -- Genetics of Childhood Obesity -- Genetic Pleiotropies of Obesity -- Functional Follow-up of Genetic Variants Using FTO as the Prime Example -- Index.
520			_aIn the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO),  has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity.   Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aEndocrinology.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aEndocrinology.
650	2	4	_aBiomedicine general.
700	1		_aGrant, Struan F.A. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461486411
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-8642-8
912			_aZDB-2-SBL
999			_c3265 _d3265