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020 _a9781493924325
_9978-1-4939-2432-5
024 7 _a10.1007/978-1-4939-2432-5
_2doi
050 4 _aRB155.8
072 7 _aMJZ
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a615.895
_223
245 1 0 _aGene Therapy for HIV and Chronic Infections
_h[electronic resource] /
_cedited by Ben Berkhout, Hildegund C.J. Ertl, Marc S. Weinberg.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2015.
300 _aXVI, 236 p. 41 illus., 35 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v848
505 0 _aGene Therapies for Hepatitis C Virus -- Recent Advances in Use of Gene Therapy to Treat Hepatitis B Virus Infection -- U1interference (U1i) for antiviral approaches -- Gene therapy strategies to block HIV-1 replication by RNA interference -- HIV and Ribozymes -- Editing CCR5: a novel approach to HIV gene therapy -- Synthetic DNA approach to Cytomegalovirus vaccine/immune therapy -- Vector-mediated antibody gene transfer for infectious diseases -- HIV latency and the non-coding RNA therapeutic landscape -- C peptides as entry inhibitors for gene therapy -- Aptamer-siRNA chimeras for HIV       .
520 _aThis volume examines gene therapy and gene transfer approaches to preventing or treating chronic virus infections, focusing on the Big Three viral pathogens- HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV).  It explores molecular antiviral strategies, including RNA interference, aptamer-siRNA chimeras, U1i interference, editing CCR5, alternative genetic vaccination by intramuscular gene transfers of virus vectors, and HIV latency in the context of non-coding RNA. This title is a volume of the American Society of Gene and Cell Therapy, a sub-series of the highly successful Advances in Experimental Medicine and Biology. In eleven illustrated chapters, leading international researchers contextualize the structure, operation, and impact of pathogens; examine the existing genetic and molecular research; and extract possible methods of preventing and treating chronic viral infections while evaluating the current body of knowledge. Authoritative and multifaceted, Gene Therapy for HIV and Chronic Infections is an ideal guide for researchers in the fields of gene therapy and immunology interested in expanding their knowledge on how to design an effective gene therapy against a viral pathogen.
650 0 _aMedicine.
650 0 _aGene therapy.
650 0 _aImmunology.
650 1 4 _aBiomedicine.
650 2 4 _aGene Therapy.
650 2 4 _aImmunology.
650 2 4 _aBiomedicine general.
700 1 _aBerkhout, Ben.
_eeditor.
700 1 _aErtl, Hildegund C.J.
_eeditor.
700 1 _aWeinberg, Marc S.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781493924318
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v848
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4939-2432-5
912 _aZDB-2-SBL
999 _c3825
_d3825