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001 978-1-4939-2845-3
003 DE-He213
005 20160405112819.0
007 cr nn 008mamaa
008 150917s2015 xxu| s |||| 0|eng d
020 _a9781493928453
_9978-1-4939-2845-3
024 7 _a10.1007/978-1-4939-2845-3
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
245 1 0 _aNovel Chemical Tools to Study Ion Channel Biology
_h[electronic resource] /
_cedited by Christopher Ahern, Stephan Pless.
250 _a1st ed. 2015.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2015.
300 _aVIII, 154 p. 33 illus., 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v869
520 _aThis volume describes chemical approaches to assess ion channel structure, function and pharmacology. Topics discussed include the use of engineered ionizable side chains to obtain information on permeation pathways and the local environment; the modification of engineered cysteine side chains, including cysteine scanning mutagenesis and the attachment of fluorescent probes and bio-reactive tethers; and the nascent use of genetic code expansion, evaluating its applications to ion channel and membrane proteins. This comprehensive text provides multifaceted perspectives on the great diversity of state-of-the-art methods which take advantage of the ever-expanding chemical toolbox to study ion channel biology. Capturing the contributions and innovations of renowned laboratory researchers in transmembrane protein study for the first time, this book is comprehensive in scope. It covers a wide array of experimental approaches: photochemistry, novel biological tools, and innovative spectroscopy, all combined with traditional techniques of electrophysiology and molecular biology. Novel Chemical Tools to Study Ion Channel Biology, part of the bestselling  Advances in Experimental Medicine and Biology series is ideal for researchers and advanced students interested in biochemistry, biophysics, fluorometry, electrophysiology, and chemical biology.
650 0 _aMedicine.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aCell Biology.
700 1 _aAhern, Christopher.
_eeditor.
700 1 _aPless, Stephan.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781493928446
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v869
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4939-2845-3
912 _aZDB-2-SBL
999 _c3841
_d3841