000 03523nam a22005295i 4500
001 978-3-319-12136-9
003 DE-He213
005 20160405112836.0
007 cr nn 008mamaa
008 141204s2015 gw | s |||| 0|eng d
020 _a9783319121369
_9978-3-319-12136-9
024 7 _a10.1007/978-3-319-12136-9
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aGenomic Instability and Cancer Metastasis
_h[electronic resource] :
_bMechanisms, Emerging Themes, and Novel Therapeutic Strategies /
_cedited by Chris Maxwell, Cal Roskelley.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aX, 247 p. 19 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v20
505 0 _aPreface.- Cancer Metastasis: Tracking and Attacking a Moving Target.- The generation, detection, and prevention of genomic instability during cancer progression and metastasis.- DNA damage response pathways in cancer predisposition and progression.- Mathematical modeling for DNA repair, carcinogenesis and cancer detection.- Animal models of metastasis.- Microenvironmental Control Of Metastatic Progression.- 7 Mechanotransduction, metastasis and genomic instability -- 8 Immunomodulation and Genomic Instability -- 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability -- Nanomedicine – Nanoparticles in Cancer Imaging and Therapy -- Index.
520 _aMetastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1  outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aMolecular biology.
650 0 _aLife sciences.
650 0 _aCell biology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aBiomedicine general.
650 2 4 _aMolecular Medicine.
650 2 4 _aLife Sciences, general.
650 2 4 _aCell Biology.
700 1 _aMaxwell, Chris.
_eeditor.
700 1 _aRoskelley, Cal.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319121352
830 0 _aCancer Metastasis - Biology and Treatment,
_x1568-2102 ;
_v20
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-12136-9
912 _aZDB-2-SBL
999 _c3924
_d3924