000 | 03523nam a22005295i 4500 | ||
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001 | 978-3-319-12136-9 | ||
003 | DE-He213 | ||
005 | 20160405112836.0 | ||
007 | cr nn 008mamaa | ||
008 | 141204s2015 gw | s |||| 0|eng d | ||
020 |
_a9783319121369 _9978-3-319-12136-9 |
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024 | 7 |
_a10.1007/978-3-319-12136-9 _2doi |
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050 | 4 | _aRC261-271 | |
072 | 7 |
_aMJCL _2bicssc |
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072 | 7 |
_aMED062000 _2bisacsh |
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082 | 0 | 4 |
_a614.5999 _223 |
245 | 1 | 0 |
_aGenomic Instability and Cancer Metastasis _h[electronic resource] : _bMechanisms, Emerging Themes, and Novel Therapeutic Strategies / _cedited by Chris Maxwell, Cal Roskelley. |
264 | 1 |
_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2015. |
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300 |
_aX, 247 p. 19 illus., 18 illus. in color. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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338 |
_aonline resource _bcr _2rdacarrier |
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347 |
_atext file _bPDF _2rda |
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490 | 1 |
_aCancer Metastasis - Biology and Treatment, _x1568-2102 ; _v20 |
|
505 | 0 | _aPreface.- Cancer Metastasis: Tracking and Attacking a Moving Target.- The generation, detection, and prevention of genomic instability during cancer progression and metastasis.- DNA damage response pathways in cancer predisposition and progression.- Mathematical modeling for DNA repair, carcinogenesis and cancer detection.- Animal models of metastasis.- Microenvironmental Control Of Metastatic Progression.- 7 Mechanotransduction, metastasis and genomic instability -- 8 Immunomodulation and Genomic Instability -- 9 Synthetic Genetic Approaches in Colorectal Cancer: Exploiting and Targeting Genome Instability -- Nanomedicine – Nanoparticles in Cancer Imaging and Therapy -- Index. | |
520 | _aMetastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aCancer research. | |
650 | 0 | _aMolecular biology. | |
650 | 0 | _aLife sciences. | |
650 | 0 | _aCell biology. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
650 | 2 | 4 | _aBiomedicine general. |
650 | 2 | 4 | _aMolecular Medicine. |
650 | 2 | 4 | _aLife Sciences, general. |
650 | 2 | 4 | _aCell Biology. |
700 | 1 |
_aMaxwell, Chris. _eeditor. |
|
700 | 1 |
_aRoskelley, Cal. _eeditor. |
|
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783319121352 |
830 | 0 |
_aCancer Metastasis - Biology and Treatment, _x1568-2102 ; _v20 |
|
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-319-12136-9 |
912 | _aZDB-2-SBL | ||
999 |
_c3924 _d3924 |