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001 978-3-319-16537-0
003 DE-He213
005 20160405112857.0
007 cr nn 008mamaa
008 150420s2015 gw | s |||| 0|eng d
020 _a9783319165370
_9978-3-319-16537-0
024 7 _a10.1007/978-3-319-16537-0
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aStem Cell Biology in Neoplasms of the Central Nervous System
_h[electronic resource] /
_cedited by Moneeb Ehtesham.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aXIII, 190 p. 16 illus., 15 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v853
505 0 _aRegulation of Subventricular Zone-Derived Cells Migration in the Adult Brain -- The SVC and Its Relationship to Stem Cell Based Neuro-oncogenesis. - Isolation and characterization of stem cells for human central nervous system malignancies. - The role of stem cells in pediatric central nervous system malignancies. - Laboratory models for central nervous system tumor stem cell research. - Radiation Therapy for Glioma Stem Cells -- Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma -- Immunobiology and Immunotherapeutic targeting of glioma stem cells -- Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.
520 _aThis volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used.   The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aNeurosciences.
650 0 _aStem cells.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aStem Cells.
650 2 4 _aNeurosciences.
700 1 _aEhtesham, Moneeb.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319165363
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v853
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-16537-0
912 _aZDB-2-SBL
999 _c4023
_d4023