000 03667nam a22005535i 4500
001 978-3-319-17305-4
003 DE-He213
005 20160405112859.0
007 cr nn 008mamaa
008 150610s2015 gw | s |||| 0|eng d
020 _a9783319173054
_9978-3-319-17305-4
024 7 _a10.1007/978-3-319-17305-4
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
245 1 0 _aRNA and DNA Diagnostics
_h[electronic resource] /
_cedited by Volker A. Erdmann, Stefan Jurga, Jan Barciszewski.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aX, 349 p. 124 illus., 78 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aRNA Technologies,
_x2197-9731
505 0 _aElectrochemical Biosensors for miRNA Detection -- Electrochemical Detection of RNA.- DNA and PNA probes for DNA Detection in Electroanalytical Systems -- DNA for Non-Nucleic Acid Sensing -- Aptamers in Oncotherapy -- Genotyping of Single Nucleotide Polymorphism -- Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA -- Fluorescent Nucleic Acid Analogues in Research and Clinical Diagnostics -- Emergent Properties and Functions of Nanoconfined Nucleic Acid Architectures -- RNA and DNA Diagnostics on Microspheres: Current and Emerging Methods -- DNA and RNA Electronic Properties for Molecular Modifications and Environmental State Diagnostics -- Mechanochemical Sensing.- Microarrays as Research Tools and Diagnostic Devices -- Quadruplex Priming Amplification (QPA) for Nucleic Acid Diagnostics.- Single-molecule strategies for DNA and RNA diagnostics -- Detection and Assessment of microRNA Expression in Human Disease.
520 _aThe aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aMolecular biology.
650 0 _aBiotechnology.
650 0 _aNucleic acids.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aNucleic Acid Chemistry.
650 2 4 _aMolecular Medicine.
650 2 4 _aBiotechnology.
700 1 _aErdmann, Volker A.
_eeditor.
700 1 _aJurga, Stefan.
_eeditor.
700 1 _aBarciszewski, Jan.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319173047
830 0 _aRNA Technologies,
_x2197-9731
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-17305-4
912 _aZDB-2-SBL
999 _c4034
_d4034