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001 978-3-319-18314-5
003 DE-He213
005 20160405112902.0
007 cr nn 008mamaa
008 150811s2015 gw | s |||| 0|eng d
020 _a9783319183145
_9978-3-319-18314-5
024 7 _a10.1007/978-3-319-18314-5
_2doi
050 4 _aQH588.S83
072 7 _aPSAK
_2bicssc
072 7 _aSCI017000
_2bisacsh
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
245 1 0 _aStem Cells in Modeling Human Genetic Diseases
_h[electronic resource] /
_cedited by Mayana Zatz, Oswaldo Keith Okamoto.
250 _a1st ed. 2015.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aXII, 147 p. 16 illus., 15 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aStem Cell Biology and Regenerative Medicine,
_x2196-8985
505 0 _aModeling Fragile X Syndrome in Human Pluripotent Cells -- Induced Pluripotent Stem Cells in Familial Dilated Cardiomyopathy.- Induced Pluripotent Stem Cells and Amyotrophic Lateral Sclerosis -- IPS Cells and Spinocerebellar Ataxia -- Induced Pluripotent Stem Cells and Vascular Disease -- iPS Cells and Cardiomyopathies -- Cancer Stem Cells and Chemoresistance -- Stem Cells in Autism Spectrum Disorders.
520 _aUsing stem cells to investigate currently untreatable human genetic diseases is the focus of this book. Several applications of the Nobel-Prize winning, revolutionary iPS cell technology are explored in detail, including in schizophrenia, autism, Huntington’s disease, Alzheimer’s disease, spinocerebellar ataxia, medulloblastoma heterogeneity, progeria, age-related macular degeneration, and muscular dystrophy . The book is divided into seven sections, each composed of authoritative and detailed chapters. The first section provides a theoretical and practical overview of stem cells in disease modeling. The following sections divide stem cell applications into various classes of pathology-  psychiatric disorders, neurodegenerative disease, neurogenesis-associated disorders, and laminopathies. Following these sections, the book discusses the future perspectives- and challenges- of iPS technology.   Broad in scope and in audience, Stem Cells in Modeling Human Genetic Diseases  for postgraduate students, scientists, and clinicians interested in applications of the rapidly developing field of stem cell research in disease modeling and drug development and its dynamic role within regenerative medicine.
650 0 _aLife sciences.
650 0 _aHuman genetics.
650 0 _aStem cells.
650 0 _aRegenerative medicine.
650 0 _aTissue engineering.
650 1 4 _aLife Sciences.
650 2 4 _aStem Cells.
650 2 4 _aRegenerative Medicine/Tissue Engineering.
650 2 4 _aHuman Genetics.
700 1 _aZatz, Mayana.
_eeditor.
700 1 _aKeith Okamoto, Oswaldo.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319183138
830 0 _aStem Cell Biology and Regenerative Medicine,
_x2196-8985
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-18314-5
912 _aZDB-2-SBL
999 _c4050
_d4050