000 03593nam a22005175i 4500
001 978-3-319-21030-8
003 DE-He213
005 20160405112917.0
007 cr nn 008mamaa
008 151112s2015 gw | s |||| 0|eng d
020 _a9783319210308
_9978-3-319-21030-8
024 7 _a10.1007/978-3-319-21030-8
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
245 1 0 _aCancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology
_h[electronic resource] /
_cedited by Sadegh Babashah.
250 _a1st ed. 2015.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2015.
300 _aXXX, 560 p. 41 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- I. The Biology of Cancer Stem Cells -- Cancer Stem Cells: A Quick Walk through the Concepts -- Cytokine Networks and Cancer Stem Cells -- Implications of CXCR4/CXCL12 Interaction for Cancer Stem Cell Maintenance and Cancer Progression -- Non-coding RNAs in Cancer and Cancer Stem Cells. Self-renewal Pathways in Mammary Stem Cells and Carcinogenesis II. Cancer Stem Cells in Human Malignancies -- Breast Cancer Stem Cells -- Lung Cancer Stem Cells -- Colorectal Cancer Stem Cells -- Pancreatic Cancer Stem Cells -- Glioblastoma Cancer Stem Cells -- Head and Neck Cancer Stem -- Leukemic and Lymphoid Stem Cells -- Leukemic Stem Cells in Acute Lymphoblastic Leukemia -- III. Novel Approaches for Targeting Cancer Stem Cells -- Targeting Key Stemness-Related Pathways in Human Cancers -- Targeting Cancer Stem Cells and the Tumor Microenvironment -- Cancer Stem Cells and Chemoresistance: Strategies to Overcome Therapeutic Resistance -- Cancer Stem Cells and Tumor Radioresistance -- Therapeutic Implications of Cancer Stem Cell: Challenges and Opportunities in Translational Studies. Index.
520 _aThe concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aHuman genetics.
650 0 _aDrug resistance.
650 0 _aMolecular biology.
650 0 _aOncology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aOncology.
650 2 4 _aDrug Resistance.
650 2 4 _aMolecular Medicine.
650 2 4 _aHuman Genetics.
700 1 _aBabashah, Sadegh.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319210292
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-21030-8
912 _aZDB-2-SBL
999 _c4114
_d4114