000 03166nam a22004575i 4500
001 978-3-658-10161-9
003 DE-He213
005 20160405112932.0
007 cr nn 008mamaa
008 150603s2015 gw | s |||| 0|eng d
020 _a9783658101619
_9978-3-658-10161-9
024 7 _a10.1007/978-3-658-10161-9
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aAlborzinia, Hamed.
_eauthor.
245 1 0 _aReal-Time Monitoring of Cancer Cell Metabolism for Drug Testing
_h[electronic resource] /
_cby Hamed Alborzinia.
264 1 _aWiesbaden :
_bSpringer Fachmedien Wiesbaden :
_bImprint: Springer Spektrum,
_c2015.
300 _aXIII, 153 p. 32 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aDrug Screening with New Perspectives -- Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip -- Anticancer Agents – Effects Measured in Real Time -- Metabolism of Cancer Cells.
520 _aHamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion.  Contents Drug Screening with New Perspectives Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip Anticancer Agents – Effects Measured in Real Time Metabolism of Cancer Cells  Target Groups Researchers and students in the fields of biotechnology and pharmacy The Author Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism.
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aPharmacology.
650 0 _aMedicinal chemistry.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMedicinal Chemistry.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783658101602
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-658-10161-9
912 _aZDB-2-SBL
999 _c4181
_d4181