000 | 03166nam a22004575i 4500 | ||
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001 | 978-3-658-10161-9 | ||
003 | DE-He213 | ||
005 | 20160405112932.0 | ||
007 | cr nn 008mamaa | ||
008 | 150603s2015 gw | s |||| 0|eng d | ||
020 |
_a9783658101619 _9978-3-658-10161-9 |
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024 | 7 |
_a10.1007/978-3-658-10161-9 _2doi |
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050 | 4 | _aRC261-271 | |
072 | 7 |
_aMJCL _2bicssc |
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072 | 7 |
_aMED062000 _2bisacsh |
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082 | 0 | 4 |
_a614.5999 _223 |
100 | 1 |
_aAlborzinia, Hamed. _eauthor. |
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245 | 1 | 0 |
_aReal-Time Monitoring of Cancer Cell Metabolism for Drug Testing _h[electronic resource] / _cby Hamed Alborzinia. |
264 | 1 |
_aWiesbaden : _bSpringer Fachmedien Wiesbaden : _bImprint: Springer Spektrum, _c2015. |
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300 |
_aXIII, 153 p. 32 illus. _bonline resource. |
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336 |
_atext _btxt _2rdacontent |
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337 |
_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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_atext file _bPDF _2rda |
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505 | 0 | _aDrug Screening with New Perspectives -- Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip -- Anticancer Agents – Effects Measured in Real Time -- Metabolism of Cancer Cells. | |
520 | _aHamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines; (ii) a detailed timeline of the metabolic response to cisplatin treatment and clear detection of the time span between start of cisplatin treatment and onset of cell death, which reflects the time required for the underlying molecular mechanisms of cell fate decision; (iii) direct functional measurement of the biological activity of a key regulatory protein of cellular metabolism following the kinetic change in respiration upon SIRT3 overexpression; and (iv) the time-resolved impact of several organometallic compounds on cell metabolism and cell morphology, including unexpected and not yet understood highly significant and specific effects on cell-cell interaction and adhesion. Contents Drug Screening with New Perspectives Real-Time Monitoring of Living Cells by a Novel Online Biosensor Chip Anticancer Agents – Effects Measured in Real Time Metabolism of Cancer Cells Target Groups Researchers and students in the fields of biotechnology and pharmacy The Author Hamed Alborzinia graduated in veterinary medicine from Shiraz University (Iran) in 2005 and continued in the Ph.D. program, now as post-Doc, with Prof. Dr. Stefan Wölfl at Heidelberg University (IPMB), using bioanalytical techniques in research on cancer cell metabolism. | ||
650 | 0 | _aMedicine. | |
650 | 0 | _aCancer research. | |
650 | 0 | _aPharmacology. | |
650 | 0 | _aMedicinal chemistry. | |
650 | 1 | 4 | _aBiomedicine. |
650 | 2 | 4 | _aCancer Research. |
650 | 2 | 4 | _aPharmacology/Toxicology. |
650 | 2 | 4 | _aMedicinal Chemistry. |
710 | 2 | _aSpringerLink (Online service) | |
773 | 0 | _tSpringer eBooks | |
776 | 0 | 8 |
_iPrinted edition: _z9783658101602 |
856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-658-10161-9 |
912 | _aZDB-2-SBL | ||
999 |
_c4181 _d4181 |