000 04401nam a22005175i 4500
001 978-4-431-55726-5
003 DE-He213
005 20160405112948.0
007 cr nn 008mamaa
008 150824s2015 ja | s |||| 0|eng d
020 _a9784431557265
_9978-4-431-55726-5
024 7 _a10.1007/978-4-431-55726-5
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
245 1 0 _aImmunopharmacogenomics
_h[electronic resource] /
_cedited by Yusuke Nakamura.
250 _a1st ed. 2015.
264 1 _aTokyo :
_bSpringer Japan :
_bImprint: Springer,
_c2015.
300 _aIX, 162 p. 30 illus., 29 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPART I TECHNOLOGIES -- 1 Deep Sequencing of T-Cell and B-Cell Receptors with Next-Generation DNA Sequencers -- 2 A TCR Sequence Data Analysis Pipeline: Tcrip -- PART II APPLICATIONS -- 3 Prediction of Drug-Induced Adverse Reactions: Skin Hypersensitivity and Liver Toxicity -- 4 Selection and Monitoring of Patients for Immunotherapy (Peptide Vaccines) -- 5 Patient Selection and Monitoring for Immunotherapies: Challenges for Immune Checkpoint Antibody and Cell Therapies -- 6 Better Understanding of Rejection After Organ Transplantation -- 7 Better Understanding of Severe Immunological Reactions: Autoimmune Diseases -- 8 Better Understanding of Severe Immunological Reactions: Food Allergy -- 9 Immune Microenvironment to Predict Response of Cancer Chemotherapy and Radiotherapy -- PART III CHALLENGES AND FUTURE -- 10 Challenges and Future Directions of Immunopharmacogenomics. .
520 _aThis book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge. .
650 0 _aMedicine.
650 0 _aCancer research.
650 0 _aHuman genetics.
650 0 _aMolecular biology.
650 0 _aPharmacology.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aCancer Research.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aMolecular Medicine.
700 1 _aNakamura, Yusuke.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9784431557258
856 4 0 _uhttp://dx.doi.org/10.1007/978-4-431-55726-5
912 _aZDB-2-SBL
999 _c4249
_d4249